Several states have banned the sale of 7-Hydroxymitragine.  First lets take a look at what 7-Hydroxymitragine (7-OH) is.

7-Hydroxymitragine

7-OH is naturally occurring alkaloid found in the kratom (Mitragyna speciosa) plant. It is an active metabolite of mitragynine, the primary compound in kratom.

Key Characteristics of 7-Hydroxymitragine

• More potent than Mitragyna speciosa
• Deals with pain relief, sedation, and euphoria
• Levels- 7-OH exists in kratom at very low levels (less than 0.05%), but it can be synthetically extracted or enhanced.

This last characteristic, that 7-OH in nature, the levels of 7-OH are very low.  A lot of states are now trying to restrict this product because its synthesized and not naturally occuring.

State Bans

The following states have banned 7-Hydroxymitragine

• Tennessee- The state bans synthetic derivatives but allows for natural kratom that contains natural levels of 7-hydroxymitragynine.  Since kratom (Mitragyna speciosa) contains a very small amount of 7-oh it is legal but the extract or concentrated versions are illegal.  This means that breaking this law is a class A misdemeanor. (Tennessee Code § 39-17-452)

 

• Georgia- As of 1/1/2025, the state of Georgia enacted the following Code § 16-13-122: 
  • Kratom products must not contain more than 150 mg of mitragynine per serving and The concentration of 7-hydroxymitragynine is limited to 0.5 mg per gram and no more than 1 mg per serving.
  • The sale of kratom products containing synthetic alkaloids, including synthetic mitragynine and synthetic 7-hydroxymitragynine, is prohibited.
  • Kratom products intended for vaporization or use with electronic devices are banned

• South Dakota- South Dakota enacted House Bill 1056 in February 2025. The law prohibits the preparation, sale, or distribution of any kratom product containing a 7-hydroxymitragynine concentration exceeding 2% of the total alkaloid content. 

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